Proteolytic cleavage of VP1-2 is required for the release of herpes simplex virus
نویسندگان
چکیده
*Corresponding author mailing address: The Marjorie B. Kovler Viral Oncology Laboratories The University of Chicago 910 East 58 th Street Chicago, IL 60637 Phone: (773) 702-1898 Fax: (773) 702-1631 E-mail: [email protected] AC CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.01919-07 JVI Accepts, published online ahead of print on 23 January 2008
منابع مشابه
Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus.
In this report we propose a model in which after the herpes simplex virus (HSV) capsid docks at the nuclear pore, the tegument protein attached to the capsid must be cleaved by a serine or a cysteine protease in order for the DNA to be released into the nucleus. In support of the model are the following results. (i) Exposure of cells at the time of or before infection to l-(tosylamido-2-phenyl)...
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تاریخ انتشار 2008